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Antioxidant Properties and UV Absorbance Pattern of Mycosporine‐Like Amino Acids Analogs Synthesized in an Environmentally Friendly Manner
Author(s) -
Andreguetti Daniel,
Stein Erika M.,
Pereira Claudio M. P.,
Pinto Ernani,
Colepicolo Pio
Publication year - 2013
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21489
Subject(s) - dpph , absorbance , antioxidant , chemistry , radical , superoxide , scavenging , organic chemistry , oxygen radical absorbance capacity , amino acid , ultraviolet , nuclear chemistry , chromatography , biochemistry , enzyme , materials science , optoelectronics
In current study, we report efficient and clean procedure for preparing mycosporine‐like amino acids (MMAs) analogs and evaluate their ultraviolet absorbance properties and antioxidant activities. The ultraviolet radiation absorbance patterns of the compounds were recorded and then used to define their molar absorptivities. The antioxidant activities were assessed using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging and superoxide radical scavenging assays. Eight of nine compounds showed good activity against superoxide radicals, as only one of the analogs exhibited a measurable IC 50 in the DPPH assay. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:305‐312, 2013; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21489