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Carbamate Protection of AChE Against Inhibition by Agricultural Chemicals
Author(s) -
Wilson Barry W.,
Rusli Francisca J.,
Yan Tam Michelle Ka,
DePeters Ed,
Henderson John D.
Publication year - 2012
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21456
Subject(s) - carbamate , agriculture , chemistry , toxicology , environmental science , microbiology and biotechnology , biology , biochemistry , ecology
The carbamate pyridostigmine bromide has been used as a pretreatment to protect individuals from the nerve agent soman. Previous research showed that pyridostigmine significantly protected human muscle acetylcholinesterase in vitro from soman and bovine red blood cell acetylcholinesterase from some organophosphorous pesticides. Research presented here demonstrates that pretreatment with other carbamates also protects acetylcholinesterase from inhibition by the pesticides chlorpyrifos‐oxon and diazinon‐oxon, but not from malaoxon. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:506‐509, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21456