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Endocrine and metabolic regulation of renal drug transporters
Author(s) -
Yacovino Lindsay L.,
Aleksunes Lauren M.
Publication year - 2012
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21435
Subject(s) - transporter , xenobiotic , hormone , renal function , kidney , reabsorption , endocrinology , renal physiology , biology , organic anion transporter 1 , medicine , endocrine system , biochemistry , enzyme , gene
Renal xenobiotic transporters are important determinants of urinary secretion and reabsorption of chemicals. In addition to glomerular filtration, these processes are key to the overall renal clearance of a diverse array of drugs and toxins. Alterations in kidney transporter levels and function can influence the efficacy and toxicity of chemicals. Studies in experimental animals have revealed distinct patterns of renal transporter expression in response to sex hormones, pregnancy, and growth hormone. Likewise, a number of disease states including diabetes, obesity, and cholestasis alter the expression of kidney transporters. The goal of this review is to provide an overview of the major xenobiotic transporters expressed in the kidneys and an understanding of metabolic conditions and hormonal factors that regulate their expression and function. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:407–421, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21435