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Effect of tin and lead chlorotriphenyl analogues on fruit fly Drosophila hydei and liposomes membrane
Author(s) -
Mitrus Slawomir,
Man Dariusz
Publication year - 2012
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.21403
Subject(s) - liposome , chemistry , chloride , membrane , lipid bilayer , food science , biochemistry , biophysics , biology , organic chemistry
This article presents the results of a study investigating the biological activity of triphenyltin chloride (TPhT) and two metalloorganic compounds, triphenyllead chloride (TPhL) and triphenylmethane chloride (TPhC), in their interaction with model membranes and the living organisms of fruit flies Drosophila hydei . The study of model membranes (sonicated liposomes) was conducted using the electron spin resonance (ESR) spin probe technique, whereas the experiment on fruit flies involved investigating their viability on media containing the studied compounds. The test results clearly demonstrate that TPhT affects fruit flies more actively than TPhL (complete lethality after 7 days of culture with a TPhT‐containing medium). No toxic effect of TPhC on fruit flies was shown. The results of the biological experiment were reflected in the physical experiment involving an ESR study of liposomes: TPhT activity manifested itself as a considerable increase in fluidity of the central region of the liposome lipid bilayer. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:162–167 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.21403