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Aberrant expression profiles of isoproterenol‐induced endoplasmic reticulum stress response genes in mouse myocardium
Author(s) -
Chen Lin,
Zhang Weiguang,
He Juan,
Dong Qin,
Li Fenglan,
Li Hui
Publication year - 2011
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.20405
Subject(s) - endoplasmic reticulum , unfolded protein response , gene , microbiology and biotechnology , gene expression , apoptosis , cardiotoxicity , chemistry , biology , medicine , biochemistry , toxicity
In this study, we identified the aberrant expression profiles of isoproterenol‐ (ISO; synthetic catecholamine)induced endoplasmic reticulum (ER) stress response genes in mouse myocardium. Mouse models of acute catecholamine cardiotoxicity were induced by ISO for 6, 12, and 24 h. We performed whole genome oligo microarrays of damaged mouse cardiac tissues, and we found 26 ER stress‐related genes whose expression changed significantly for at least one time point. The functional analysis of those genes indicated that myocardial cells were protected by increasing folding capacity, inhibiting general protein translation, and promoting the degradation of misfolded proteins; however, some of them underwent apoptosis in the early stage of ER stress after ISO induced. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:382–385 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.20405