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Antioxidant role of coumarin on streptozotocin–nicotinamide‐induced type 2 diabetic rats
Author(s) -
Rajarajeswari Narayanasamy,
Pari Leelavinothan
Publication year - 2011
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.20395
Subject(s) - chemistry , antioxidant , lipid peroxidation , nicotinamide , superoxide dismutase , glutathione peroxidase , streptozotocin , thiobarbituric acid , medicine , endocrinology , glutathione , diabetes mellitus , catalase , insulin , biochemistry , enzyme
The purpose of this study was to investigate the antioxidant role of coumarin on streptozotocin–nicotinamide‐induced Type 2 diabetic rats. In experimental rats, the levels of plasma glucose, insulin, and the levels of thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes, and the activities of superoxide dismutase, catalase, glutathione‐S‐transferase, and glutathione peroxidase were assayed in liver and kidney. Diabetic rats showed elevated levels of plasma glucose and lipid peroxidation markers and reduced plasma insulin and antioxidant enzymes. Oral administration of coumarin resulted in a significant reduction in the plasma glucose and lipid peroxides and a significant increase in the plasma insulin and antioxidant enzymes. Chronic treatment of coumarin remarkably restored the normal status of the histopathological changes observed in the selected tissues. It can be concluded that coumarin has antioxidant effect in Type 2 diabetic rats. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:355–361 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.20395