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Chronic alcohol consumption augments loss of sialic acid residues and alters erythrocyte membrane charge in type II diabetic patients
Author(s) -
Degirmenci Serkan,
Akalin Aysen,
Kartkaya Kazım,
Kanbak Güngör
Publication year - 2008
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.20243
Subject(s) - medicine , alcohol , endocrinology , erythrocyte membrane , sialic acid , diabetes mellitus , chemistry , type 2 diabetes , sialidase , biochemistry , membrane , enzyme , neuraminidase
Abstract In this study, the effects of alcohol consumption on erythrocyte membrane properties in type 2 diabetic patients were investigated. Therefore, we measured total and lipid‐bound sialic acid (LSA) levels, sialidase activities, and erythrocyte membrane negative charge. Three groups, including control group ( n = 20), alcohol‐consuming diabetic patients group ( n = 14), and diabetic patients without alcohol consumption group ( n = 42), were created. Plasma total sialic acid (TSA) levels of the alcohol‐consuming diabetic group were elevated as compared to the healthy control and diabetic group ( p < 0.001 and p < 0.01, respectively). TSA levels of the diabetic group were significantly elevated as compared to the healthy control group ( p > 0.001). Plasma LSA levels of the alcohol‐consuming diabetic group were higher than that in the healthy control and diabetic group ( p < 0.05 and p < 0.05, respectively). LSA levels of the diabetic group were found to be high as compared to the healthy control group ( p < 0.05). Plasma sialidase activities of the alcohol‐consuming diabetic group and diabetic group were significantly elevated as compared to the healthy control group ( p < 0.05 and p < 0.05, respectively). Sialidase activities of the alcohol‐consuming diabetic group were elevated as compared to the diabetic group, but this was not statistically significant ( p > 0.05). Erythrocyte membrane negativity levels of the alcohol‐consuming diabetic group and diabetic group were significantly decreased ( p < 0.001 and p < 0.001, respectively) as compared to the healthy control group. Erythrocyte membrane negativity levels of the alcohol‐consuming diabetic group were decreased as compared to the diabetic group, but this was not statistically significant ( p > 0.05). In conclusion, our results indicate that chronic alcohol consumption may augment membrane alterations in type 2 diabetic patients. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:320–327, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/jbt.20243