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Antihyperlipidemic effect of D ‐pinitol on streptozotocin‐induced diabetic wistar rats
Author(s) -
Geethan P. K. M. Anu,
Prince P. Stanely Mainzen
Publication year - 2008
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.20218
Subject(s) - endocrinology , medicine , streptozotocin , very low density lipoprotein , cholesterol , chemistry , diabetes mellitus , intraperitoneal injection , low density lipoprotein , kidney , high density lipoprotein , insulin , lipoprotein
D ‐pinitol (3‐ O ‐methyl‐chiroinositol), an active principle of the traditional antidiabetic plant, Bougainvillea spectabilis , is claimed to exert insulin‐like effects. This study was undertaken to evaluate the effect of D ‐pinitol on lipids and lipoproteins in streptozotocin (STZ)‐induced diabetic Wistar rats. Rats were made type II diabetic by single intraperitoneal injection of STZ at a dose of 40 mg/kg body weight. STZ‐induced diabetic rats showed significant ( p < 0.05) increase in the levels of blood glucose and total cholesterol, triglycerides, free fatty acids, and phospholipids in serum, liver, kidney, heart, and brain. The levels of low‐density lipoprotein (LDL) and very low‐density lipoprotein (VLDL) cholesterol were significantly increased, and the level of high‐density lipoprotein (HDL) cholesterol was significantly decreased in diabetic rats Oral administration of D ‐pinitol to STZ‐induced diabetic rats showed significant ( p < 0.05) decrease in the levels of blood glucose and total cholesterol, triglycerides, free fatty acids, and phospholipids in serum, liver, kidney, heart, and brain. The D ‐pinitol also lowered significantly ( p < 0.05) LDL and VLDL cholesterol levels and increased significantly ( p < 0.05) HDL cholesterol levels in the serum of diabetic rats. Thus, the present study clearly showed the antihyperlipidemic effect of D ‐pinitol in STZ‐induced type II diabetic rats. © 2008 Wiley Periodicals, Inc. J Biochem Mol Toxicol 22:220–224, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/jbt.20218