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Cigarette smoke and dopaminergic system
Author(s) -
Miller Leah R.,
Mukherjee Shyamali,
Ansah Twum A.,
Das Salil K.
Publication year - 2007
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.20197
Subject(s) - dopaminergic , cigarette smoke , smoke , chemistry , neuroscience , medicine , environmental health , psychology , dopamine , organic chemistry
It has been reported that there is an ameliorative effect of cigarette smoking on certain neurological responses and neurodegenerative disorders. The purpose of this study was to examine the neurochemical and neurobehavioral response of cigarette smoke (CS) in the adult male guinea pig brain. Both acute and chronic CS exposure enhanced locomotor behavior and caused a decrease in midbrain dopamine (DA) levels and corresponding increase in 3,4‐dihydroxyphenylacetic acid (DOPAC) levels. In addition, CS caused a significant increase in the protein levels of the dopamine D 1 and D 2 receptors. CS caused a significant increase in the binding capacity of the D 1 receptor and a significant decrease in the binding capacity of D 2 . Furthermore, CS caused a significant increase in the binding capacity of the dopamine transporter (DAT). The mechanism by which cigarette smoke exposure increases locomotor activity remains to be elucidated but may include modulation of dopamine neuron activity that emerges after repeated direct smoke exposure. © 2007 Wiley Periodicals, Inc. J Biochem Mol Toxicol 21:325–335, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/jbt.20197