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Time‐course of lipid peroxidation in different organs of mice treated with Echis pyramidum snake venom
Author(s) -
Asmari Abdurrahman Al,
Moutaery Khalaf Al,
Manthari Rajamohamed Abbas,
Khan Haseeb Ahmad
Publication year - 2006
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.20121
Subject(s) - lipid peroxidation , snake venom , venom , chemistry , biology , biochemistry , oxidative stress
This study examined the effect of Echis pyramidum ( EP ) venom on time‐course of lipid peroxidation in different vital organs of mice. Adult male Swiss albino mice were injected with EP venom (2 mg/kg, i.p.); control mice received vehicle alone (normal saline). Mice were killed at 1, 3, 6, 12, and 24 h postenvenomation. The liver, lung, kidney, heart, and brain (cerebrum and cerebellum) were collected for the estimation of malondialdehyde (MDA), an index of lipid peroxidation. The results of this study showed that a single injection of EP venom caused a significant lipid peroxidation in all the organs studied. The onset of lipid peroxidation was as early as 1 h and persisted for several hours, suggesting an important role of oxidative stress in the cytotoxicity of EP venom. © 2006 Wiley Periodicals, Inc. J Biochem Mol Toxicol 20:93–95, 2006; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/jbt.20121