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Protective effect of arabic gum against cardiotoxicity induced by doxorubicin in mice: A possible mechanism of protection
Author(s) -
AbdAllah Adel RA,
AlMajed Abdulhakeem A.,
Mostafa Adel M.,
AlShabanah Othman A.,
Din Ayman Gamal El,
Nagi Mahmoud N.
Publication year - 2002
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.10046
Subject(s) - cardiotoxicity , chemistry , pharmacology , superoxide , doxorubicin , malondialdehyde , superoxide dismutase , antioxidant , lipid peroxidation , biochemistry , toxicity , chemotherapy , enzyme , medicine , organic chemistry
Arabic gum (AG) is a naturally occurring compound that has been proposed to posses potent antioxidant activity. In this study, the possible effects whereby AG could protect against cardiotoxicity induced by doxorubicin (DOX) in mice were carried out. Administration of single dose of DOX (15 mg/kg, i.p.) induced cardiotoxicity 72 h, manifested biochemically by a significant elevation of serum creatine kinase (CK) (EC 2.7.3.2). In addition, cardiotoxicity was further confirmed by the significant increase in lipid peroxides measured as malondialdehyde (MDA). Administration of AG (25 g/kg) orally for 5 days before and 72 h after DOX injection produced a significant protection against cardiotoxicity induced by DOX. This was evidenced by significant reductions in serum CK and cardiac lipid peroxides. The effect of AG was examined on the superoxide anion radical generated by enzymatic and nonenzymatic methods. The results indicate that AG is a potent superoxide scavenger. The superoxide scavenging effect of AG may explain, at least in part, the protective effect of AG against cardiotoxicity induced by DOX. © 2002 Wiley Periodicals, Inc. J Biochem Mol Toxicol 16:254–259, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10046