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Discovery in toxicology: Mediation by gene expression array technology
Author(s) -
Hamadeh Hisham K.,
Bushel Pierre,
Paules Richard,
Afshari Cynthia A.
Publication year - 2001
Publication title -
journal of biochemical and molecular toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.526
H-Index - 58
eISSN - 1099-0461
pISSN - 1095-6670
DOI - 10.1002/jbt.10006
Subject(s) - toxicogenomics , identification (biology) , computational biology , genomics , mechanism (biology) , toxicology , biology , data science , bioinformatics , computer science , genetics , gene , gene expression , genome , epistemology , philosophy , botany
Toxicogenomics is a term that represents the merging of toxicology with novel genomics techniques. Data generated in the new‐age era of toxicology is relatively complex, requires new bioinformatics tools for adequate interpretation, and allows for the rapid generation of testable hypotheses. Hazard identification and risk assessment processes will advance from the use of genomics techniques, which will lead to greater understanding of mechanism(s) of action of toxicants, development of novel biomarkers of exposure and effect, and better identification of sensitive subpopulations. © 2001 John Wiley & Sons, Inc. * This article is a US Government work and, as such, is in the public domain in the United States of America. J Biochem Mol Toxicol 15:231–242, 2001