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2006 Abstracts: Twenty‐Eighth Annual Meeting of the American Society for Bone and Mineral Research: Pennsylvania Convention Convention Center Philadelphia, Pennsylvania, USA, September 15–19, 2006
Author(s) -
Tsuneo Kondo,
Riko Kitazawa,
S. H. Liu,
Ronald C. Wek,
Hajime Yokota,
Taku Matsubara,
Atsushi Yamaguchi,
Robert N. Nishimura,
Takahiro Yoneda,
P Cogan,
Baruch Frenkel,
Tae Woong Noh,
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Yawaka •',
Masato Tamura,
Masami Sato,
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Publication year - 2006
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650211407
Subject(s) - medicine , osteopenia , osteoporosis , femoral neck , bone mineral , dentistry , surgery
Increasingly similarities between the cell biology of the vascular system and the skeletal system are being recognized perhaps related to their common mesodermal origin. In particular similarities between cytokines regulating the activity and pathology of the two tissues have been noted. In this regard osteoprotogerin (OPG) a decoy receptor for RANK ligand, a potent activator of osteoclast resorptive activity in bone, has been advanced as a potential risk factor for cardiovascular disease. In a six year cohort population study of 1333 postmenopausal women mean age 75.2 ± 2.7 yrs, serum OPG concentrations above the median were associated with an increased relative risk of being diagnosed with coronary artery disease (CAD) and or dying of CAD [HR 1.79 (1.05-3.06)] after adjusting for other CAD risk factors including age, treated hypertension, hypercholesterolemia, diabetes, smoking status and previous HRT. OPG values above the median were associated with an increased relative risk ofCAD diagnosis [HR 2.07 (1.04-4.30)] but not CAD death. Genotyping the OPG gene did not contribute further information on the association between OPG and CAD risk or events. These data suggest that further work to elucidate the similarities and differences between the cell biology of the skeletal and vascular system would be productive. Second if these data are replicated OPG may become a clinically useful independent risk factor for CAD