Premium
Effect of parathyroid hormone on renal calbindin‐D28k
Author(s) -
Hemmingsen Claus,
Staun Michael,
Lewin Ewa,
Nielsen Palle K.,
Olgaard Klaus
Publication year - 1996
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650110807
Subject(s) - parathyroid hormone , endocrinology , medicine , hormone , calcium
The present investigation was conducted to examine the effects of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) on renal calbindin‐D28k in rats. Four groups of studies were performed: (1) parathyroidectomy (PTX) or a sham operation followed by infusion of 1,25‐dihydroxyvitamin D (1,25[OH] 2 D) or vehicle; (2) infusions of PTH(1‐34), PTH(1‐84), 1,25(OH) 2 D, or vehicle; (3) infusion of PTHrP(1‐34), PTHrP (1‐86), PTH(1‐34), or vehicle; and (4) injections of calcium or vehicle. PTX reduced renal calbindin‐D28k levels even when plasma concentrations of 1,25(OH) 2 D were kept constant by infusion of 1,25(OH) 2 D. Infusions of PTH(1‐34), PTH(1‐84), and 1,25(OH) 2 D all increased renal calbindin‐D28k and plasma calcium, whereas PTHrP(1‐34) and PTHrP(1‐86) increased renal calbindin‐D28k before an increase of plasma calcium took place. Hypercalcemia induced by the injection of calcium did not affect the levels of renal calbindin‐D28k. The present data suggest that PTH and PTHrP exert a direct effect on renal calbindin‐D28k, which is not mediated by changes of 1,25(OH) 2 D or calcium.