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Total body calcium and bone mineral content: Comparison of dual‐energy X‐ray absorptiometry with neutron activation analysis
Author(s) -
Ellis K.J.,
Shypailo R.J.,
Hergenroeder A.,
Perez M.,
Abrams S.
Publication year - 1996
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650110616
Subject(s) - bone mineral content , neutron activation analysis , chemistry , calcium , bone mineral , nuclear medicine , dual energy , bone mass , skeleton (computer programming) , medicine , radiochemistry , anatomy , osteoporosis , organic chemistry
The aim of this study was to compare the dual‐energy X‐ray absorptiometry (DXA) measurement of bone mass with an independent measure of body calcium obtained by neutron activation analysis (NAA). Total body bone mineral content (BMC) was measured using DXA in 46 subjects in the age range 5–47 years (17 children, 28 young women, and 1 adult male). Total body calcium (TBCa) was measured in the same subjects by in vivo NAA. The correlation between the two measures of bone mass was highly significant (BMC[g] = 3.22 × TBCa[g] – 51.4, r > 0.98, p < 0.0001, SEE BMC = 122.7 g). When BMC was the independent parameter, the SEE TBCa was 37.5 g. Bland‐Altman analysis indicated a mean difference of 2.8 g with a standard error + 4.7 g for TBCa NAA versus TBCa DXA when the BMC values were converted to TBCa. The relative change in bone mass (ΔTBCa/ABMC) for DXA was higher than that reported for dual‐photon absorptiometry versus NAA. The findings presented in this study provide translational equations among the DXA and NAA measurements and for the conversion of total body BMC to TBCa in children and young adults.