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Three‐dimensional nuclear magnetic resonance microimaging of trabecular bone
Author(s) -
Chung HsiaoWen,
Wehrli Felix W.,
Williams John L.,
Wehrli Suzanne L.
Publication year - 1995
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650101005
Subject(s) - isotropy , stereology , voxel , nuclear magnetic resonance , magnetic resonance imaging , orientation (vector space) , trabecular bone , materials science , tensor (intrinsic definition) , resolution (logic) , magnetic resonance microscopy , biomedical engineering , physics , optics , geometry , mathematics , spin echo , computer science , osteoporosis , medicine , artificial intelligence , radiology , endocrinology
The conventional approach to measuring structural parameters in trabecular bone rests on stereology from optical images, derived from sections of embedded bone. In order to provide data that are statistically representative of a sufficiently large volume, multiple sections need to be analyzed in each of the three orthogonal planes. In this work, an alternative technique is presented which is based on three‐dimensional (3D) volumetric proton nuclear magnetic resonance (NMR) microimaging. The method presented provides images from 9 × 9 × 4 mm 3 volumes of defatted bone specimens in 15–20 minutes scan time at isotropic resolution corresponding to (78 μm) 3 voxel size. Surface‐rendered images of bovine and human trabecular bone are shown and an algorithm was developed and implemented for determining the orientation and magnitude of the principal axes of the mean intercept length tensor.