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Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women
Author(s) -
Garnero Patrick,
Borel Olivier,
SornayRendu Elizabeth,
Delmas Pierre D.
Publication year - 1995
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650100902
Subject(s) - taqi , calcitriol receptor , endocrinology , medicine , bone remodeling , bone mineral , genotype , osteoporosis , peak bone mass , vitamin d and neurology , bone density , bone resorption , polymorphism (computer science) , biology , genetics , gene
Bone mineral density (BMD) is under strong genetic control. Polymorphisms at the vitamin D receptor (VDR) gene have been recently suggested to account for up to 75% of this genetic effect. We analyzed these polymorphisms, i.e., that of Bsm I, Taq I, and Apa I restriction enzymes by PCR of the DNA in 189 healthy premenopausal women aged 31 to 57 years. For the Bsm I polymorphism they were 17% BB homozygotes, 51% Bb heterozygotes, and 32% bb homozygotes, genotype frequencies that are very similar to those previously reported in other Caucasian populations of north European ancestry. Women in the three genotypes for any of the three polymorphisms were matched for age and did not differ in body weight, height, physical activity, nor smoking habits. We found no relationship between the genotype for any of the three polymorphisms nor bone formation and resorption rate assessed by five specific biochemical markers of bone turnover nor with BMD measured at the spine, proximal femur, forearm, and whole body by dual‐energy X‐ray absorptiometry (DXA). We concluded that these polymorphisms are not predictive of bone turnover nor BMD in a sample of healthy premenopausal women drawn from the French population.