Premium
Bone sialoprotein is localized to the root surface during cementogenesis
Author(s) -
Macneil R.L.,
Sheng N.,
Strayhorn C.,
Fisher L.W.,
Somerman M.J.
Publication year - 1994
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650091013
Subject(s) - bone sialoprotein , cementogenesis , cementum , dental follicle , dental alveolus , connective tissue , chemistry , mineralization (soil science) , dental cementum , cementoblast , microbiology and biotechnology , dentistry , pathology , osteocalcin , biology , medicine , stem cell , dentin , alkaline phosphatase , organic chemistry , nitrogen , enzyme , biochemistry
Bone sialoprotein (BSP), an RGD‐containing protein with cell attachment properties, is believed to play a regulatory role in the biomineralization of various connective tissues. To determine its possible role in tooth root formation, murine dentoalveolar tissues at sequential phases of development were analyzed immunohistochemically for the presence of BSP. BSP was localized to alveolar bone and cementum at time points associated with initial mineralization of these tissues. In addition, northern blot analyses of dental follicle tissue at day 27 of tooth development indicated that BSP mRNA is expressed by dental follicle cells at a time point coincident with the initiation of cementogenesis on the peripheral tooth root surface. Collectively, these findings indicate that BSP may play an important role in the formation and mineralization of cementum.