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Serum parathormone profile during surgical treatment of hyperfunctioning parathyroid adenoma: A multicompartmental model
Author(s) -
Duquenne Marc,
Weryha Georges,
Kaminsky Pierre,
De Talance Nicole,
Mathieu Pierre,
Leclere Jacques
Publication year - 1994
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650090908
Subject(s) - immunoradiometric assay , parathyroid hormone , medicine , endocrinology , confidence interval , adenoma , parathyroid adenoma , parathyroid gland , urology , chemistry , radioimmunoassay , calcium
Patterns of intact parathyroid hormone (iPTH) elimination and subsequent recovery of parathyroid function were studied in seven patients undergoing surgical removal of solitary hyperfunctioning parathyroid adenoma. Using a sensitive two‐site immunoradiometric assay, iPTH levels were measured pre, peri‐, and postoperatively. Blood samples were taken at very early and at late stages, including 3, 6, 9, and 15 minutes and 48, 72, and 96 h after adenomectomy. A biexponential formula was calculated to fit the decreasing values of iPTH in all patients. The PTH half‐life in the early phase was 1.4 + 1.1 minutes (95% confidence limits). The PTH half‐life in the second phase was 64.45 + 32.19 minutes (95% confidence limits). A third phase is represented by a slow, linear increase in plasma iPTH values as a result of the recovery of healthy suppressed parathyroid glands. The extrapolation to baseline of the later phase shows that the recovery of normal parathyroid function begins as soon as 240 minutes after adenomectomy and is independent of the decrease in PTH of adenomatous origin. All individual results were consistent with this model. Five patients had iPTH values below 5 pg/ml, one had 15 pg/ml, and the last had 27 pg/ml 5 h after parathyroid adenomectomy. The recovery of the hormonal activity of the remaining glands occurred rapidly. By the postoperative hour 24 the mean serum iPTH concentration was 12.28 + 8.07 pg/ml. The intraoperative serum iPTH concentration offers a model to assess both recovery of hormonal secretion from functionally suppressed parathyroid glands and disappearance of parathyroid hormone.