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Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral density
Author(s) -
Ammann Patrick,
Rizzoli René,
Caverzasio Joseph,
Shigematsu Takashi,
Slosman Daniel,
Bonjour JeanPhilippe
Publication year - 1993
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650081212
Subject(s) - bone resorption , bone mineral , endocrinology , bisphosphonate , resorption , medicine , osteoporosis , calcium , chemistry
Bone resorption inhibitors, such as bisphosphonates, are potentially useful in treatments aimed at increasing bone mass. Among bisphosphonates, tiludronate has proven efficacious in preventing bone loss in postmenopausal women. However, it is not clearly established whether bisphosphonates are more potent when given intermittently or continuously. We investigated the effects of tiludronate on (1) retinoid‐stimulated bone resorption in thyroparathyroidectomized rats, (2) calcium balance in intact rats, and (3) bone mineral density (BMD) as measured by dual‐energy x‐ray absorptiometry at the levels of the lumbar spine, tail, and tibia in 6‐month‐old rats made osteoporotic by ovariectomy (OVX), in which an intermittent cyclic schedule of treatment was compared to continuous administration. Tiludronate induced a dose‐dependent decrease in retinoid‐stimulated bone resorption. It increased the intestinal absorption and body retention of calcium. In OVX rats it caused a time‐ and dose‐dependent increase in BMD at the level of the three investigated sites, the effects being maintained for at least 8 weeks after the end of therapy. Continuous and intermittent cyclic regimens appeared to induce similar increases in BMD. These results indicate that tiludronate is efficacious in decreasing bone resorption and increasing calcium balance and bone mineral density in rats.