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Determinants of remission of paget's disease of bone
Author(s) -
Patel S.,
Stone M.D.,
Coupland C.,
Hosking D.J.
Publication year - 1993
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650081209
Subject(s) - paget's disease of bone , medicine , alkaline phosphatase , gastroenterology , population , bone remodeling , bone disease , disease , endocrinology , surgery , osteoporosis , biology , enzyme , biochemistry , environmental health
Bisphosphonates are a safe and effective treatment for Paget's disease of bone, but little information is available about the factors influencing the duration of remission so obtained. We assessed 60 patients with Paget's disease treated with disodium pamidronate (APD). The mean duration of remission was 9.5 months (range 3–25). The major influences were the initial pretreatment alkaline phosphatase (ALP; r = −4.6, p < 0.0001), minimum posttreatment ALP ( r = −0.51, p < 0.0001), and the rate of response of bone turnover to the first dose of APD ( r = 0.61, p < 0.0001). Multiple linear regression showed that the initial response to treatment was the most significant influence. Also, despite a minimum ALP within the normal range, the duration of remission varied considerably (4–25 months). This may be due to the difficulties in applying a population‐based normal range to individuals.