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Intranasal calcitonin suppresses increased bone resorption during short‐term immobilization: A double‐blind study of the effects of intranasal calcitonin on biochemical parameters of bone turnover
Author(s) -
van der Wiel H.E.,
Lips P.,
Nauta J.,
Kwakkel G.,
Hazenberg G.,
Netelenbos J.C.,
van der Vijgh W.J.F.
Publication year - 1993
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650081208
Subject(s) - calcitonin , bone remodeling , medicine , bone resorption , endocrinology , nasal administration , resorption , creatinine , n terminal telopeptide , placebo , chemistry , osteocalcin , pharmacology , alkaline phosphatase , biochemistry , enzyme , alternative medicine , pathology
Abstract Immobilization is associated with increased bone resorption and decreased bone formation. We evaluated in a double‐blind trial the effect of intranasal administration of salmon calcitonin on biochemical parameters of bone turnover in 32 patients immobilized for a prolapsed intervertebral disk. Calcitonin in a dose of two times 200 IU/day partially inhibited the increase in the fasting 2 h urinary hydroxyproline/creatinine ratio (OHPr/Cr) and calcium/creatinine ratio (Ca/Cr). The increase in OHPr/Cr was 40% less in the calcitonin group compared to the placebo group ( P = 0.01), and the increase in Ca/Cr was 80% less in the calcitonin group ( P = 0.04). Calcitonin also partially inhibited the increase in serum cross‐linked carboxyl‐terminal telopeptide of collagen type I ( P < 0.05). The decrease in serum 1,25‐dihydroxyvitamin D after 10 days of immobilization was significantly less in the calcitonin‐treated group than in the placebo group (14 versus 29%, respectively; P < 0.05). Intranasal calcitonin did not influence the pain scores as measured with a visual analog scale (VAS). The tolerability of the nasal calcitonin preparation was excellent. We conclude that nasal salmon calcitonin counteracts the early increase in bone resorption induced by immobilization.