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Effect of different amounts of sodium intake for 4 months on calcium metabolism in normal and oophorectomized rats
Author(s) -
Chan Ellen LaiPing,
Swaminathan R.
Publication year - 1993
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650081005
Subject(s) - hydroxyproline , calcium , endocrinology , excretion , medicine , urinary calcium , chemistry , sodium , urinary system , hypercalciuria , urine , organic chemistry
The effects of different amounts of salt intake on urinary calcium and hydroxyproline (OHP) excretion were studied in oophorectomized (O) and sham‐operated (S) rats on normal calcium diet. Groups of O and S rats were given either tap water or 2, 6, or 18 g/liter of NaCl to drink. Urinary excretion of sodium, calcium, and OHP was monitored at 0, 2, and 4 months. Urinary excretion of calcium and OHP increased with increasing salt intake ( P < 0.001 by ANOVA) in S and O groups. Oophorectomy did not have any additional effect on calcium or OHP excretion. We conclude that increased salt intake causes increased excretion of calcium and OHP and oophorectomy does not further aggravate the loss.