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Detection and measurement of vitamins K 1 and K 2 in human cortical and trabecular bone
Author(s) -
Hodges S.J.,
Bejui J.,
Leclercq M.,
Delmas P.D.
Publication year - 1993
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650080814
Subject(s) - cortical bone , trabecular bone , chemistry , anatomy , osteoporosis , medicine
Vitamin K plays an essential role in the gamma carboxylation of the gla‐containing proteins of bone matrix, such as osteocalcin. We have measured the concentration of vitamin K 1 (VK) and of the menaquinones MK‐6, MK‐7, and MK‐8, the three major vitamin K 2 moieties, in trabecular and cortical bone taken from the femoral neck of patients undergoing hip replacement. Both bone compartments were found to contain large amounts of VK, MK‐6, MK‐7, and MK‐8. Concentrations were as high as those reported for the liver, the major storage organ for vitamin K. Further research is required to examine the association between vitamin K in bone and the gamma carboxylation of vitamin K‐dependent bone proteins.