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Lack of effects of neutralization of parathyroid hormone‐related protein on calcium homeostasis in neonatal mice
Author(s) -
Kukreja Subhash C.,
D'Anza James J.,
Melton Mary E.,
Wimbiscus Sarah A.,
Grill Vivian,
Martin John T.
Publication year - 1991
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650061109
Subject(s) - calcium , parathyroid hormone related protein , medicine , calcium metabolism , endocrinology , homeostasis , parathyroid hormone , neutralization , hormone , amino acid , chemistry , antibody , immunology , biochemistry
Large quantities of parathyroid hormone‐related protein (PTHrP) are present in the milk of various species. It has been suggested that PTHrP may play a role in neonatal calcium homeostasis. In the present study we evaluated the effect of neutralization of amino‐terminal PTHrP activity by passive immunization in 1‐day‐old mouse pups. Neutralization of amino‐terminal PTHrP activity had no significant effect on serum calcium or whole‐body calcium content in the neonatal mice. In additional studies, we demonstrated that subcutaneous administration of PTHrP‐(1–34) increased serum calcium, whereas oral administration had no significant effect in 3‐day‐old pups. The studies therefore demonstrate that the amino terminus of PTHrP may not play a significant role in neonatal calcium homeostasis. Local effects of PTHrP cannot be excluded by the results of the present study.