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Estrogen therapy and variable‐resistance weight training increase bone mineral in surgically menopausal women
Author(s) -
Notelovitz Morris,
Martin Daniel,
Tesar Rogene,
Khan Farouk Y.,
Probart Claudia,
Fields Carol,
McKenzie Lynda
Publication year - 1991
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650060609
Subject(s) - estrogen , bone mineral , medicine , endocrinology , appendicular skeleton , estrogen replacement therapy , hormone replacement therapy (female to male) , urology , osteoporosis , testosterone (patch) , anatomy
This study was undertaken to examine the effect of estrogen replacement therapy alone and estrogen replacement therapy plus variable‐resistance weight training on the bone mineral content of surgically menopausal women. A total of 20 surgically menopausal women were randomized and treated with either 0.625 mg conjugated estrogen daily or the same dose of estrogen plus a closely monitored exercise program involving the use of Nautilus muscle strengthening/endurance equipment. After 1 year's observation, the bone mineral density (BMD) of the spine determined by dual‐photon absorptiometry increased in the exercising subjects by 8.3 ± 5.3% ( p = 0.004), 95% confidence limits (CL) 3.9–12.8%; the group with estrogen replacement therapy alone maintained their BMD: 1.5 ± 12.4% ( p = 0.36; 95% CL = −6.9–9.8%). The total body BMD of the exercising group increased by 2.1 ± 1.5% ( p = 0.003; 95% CL = 0.8–3.3%); the nonexercising women had a nonsignificant 0.6 ± 2.9% change ( p = 0.30; 95% CL = −1.4–2.5%). A significant increase of 4.1 ± 4.3% ( p = 0.01; 95% CL = 0.8–7.4%) in the radial midshaft BMD of the exercising group was found; the estrogen alone group recorded a nonsignificant change of −0.3 ± 3.1% ( p = 0.33; 95% CL = −1.7–2.4%). The results of this study suggest that variable‐resistance training in estrogen‐replete women adds bone to both the axial and appendicular skeleton.