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Mitogenic action(s) of fluoride on osteoblast line cells: Determinants of the response In Vitro
Author(s) -
Farley John R.,
Tarbaux Nanine,
Hall Susan,
Baylink David J.
Publication year - 1990
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650051371
Subject(s) - osteoblast , cell growth , in vitro , fluoride , cell culture , microbiology and biotechnology , bone cell , chemistry , cell , mitogen activated protein kinase , endocrinology , medicine , biology , biochemistry , inorganic chemistry , genetics
Clinically effective (osteogenic) concentrations of fluoride (5–30 μM) also have direct effects on skeletal tissues in vitro , to increase bone formation and osteoblast line cell proliferation. The effect on cell proliferation was specific for bone cells, modulated by systemic skeletal effectors, and dependent on (a) the [P i ] in the medium, (b) the presence of a bone cell mitogen, and (c) mitogen‐responsive osteoprogenitor cells. Together, these data indicate that fluoride increases bone formation in vitro by increasing osteoprogenitor cell proliferation and that fluoride increases osteoprogenitor cell proliferation by enhancing the activity of bone cell mitogens.