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Comparative study of fluoride bioavailability following the administration of sodium fluoride alone and in combination with different calcium salts
Author(s) -
Briançon D.,
D'Aranda P.,
Quillet P.,
Duplan B.,
Chapuy M. C.,
Arlot M.,
Meunier P. J.
Publication year - 1990
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650051310
Subject(s) - bioavailability , fluoride , sodium fluoride , calcium , volunteer , chemistry , pharmacokinetics , sodium , pharmacology , medicine , inorganic chemistry , organic chemistry , biology , agronomy
To assess whether an interval of a few hours would be advisable between an intake of sodium fluoride (NaF) and that of calcium salts when treating osteoporotic patients with vertebral collapse, we carried out three pharmacokinetic studies in 12 healthy fasting volunteer subjects to compare the fluoride bioavailability provided by NaF alone and NaF combined with two calcium salts. The results were as follows: (1) When NaF is accompanied by calcium, the fluoride peak level is lower and delayed. (2) Fluoride absorption varied greatly among individuals in both experiments, but none of the 6 subjects proved to be nonabsorbers. (3) The areas under the curves obtained with each of the three preparations were not significantly different, but 24‐h urinary fluoride was significantly lower in volunteers receiving simultaneously NaF and calcium salts than in volunteers receiving only NaF.