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Rapid publication a chromogranin a‐derived peptide differentially regulates the secretion of calcitonin gene products
Author(s) -
Deftos Leonard J.,
HogueAngeletti Ruth,
Chalberg Cheryl,
Tu Su
Publication year - 1990
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650050913
Subject(s) - chromogranin a , secretion , calcitonin gene related peptide , calcitonin , peptide hormone , endocrinology , medicine , peptide , hormone , neuropeptide , chemistry , biology , biochemistry , receptor , immunohistochemistry
We studied the regulation of the secretion of CT and CGRP by chromogranin A (CgA)‐derived peptides in a human lung tumor cell line. The amino‐terminal peptide of CgA, CgA1‐40, stimulated the secretion of CGRP and inhibited the secretion of CT; both effects occurred in a dose‐dependent manner. These studies demonstrate a differential effect of a CgA‐derived peptide on two products of the CT gene, CT itself and CGRP. CgA may be processed at its multiple dibasic sites to peptides that specifically regulate the secretion of its coresident hormones, in this case two calcitonin gene products that are present in the same secretory vesicle. This novel mechanism represents a new pathway for the control of calcium regulating hormones.