z-logo
Premium
Heterogeneity of human bone
Author(s) -
Ninomiya James T.,
Tracy Russell P.,
Calore James D.,
Gendreau Mark A.,
Kelm Robert J.,
Mann Kenneth G.
Publication year - 1990
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650050906
Subject(s) - osteonectin , osteocalcin , cortical bone , skeleton (computer programming) , endocrinology , medicine , bone remodeling , trabecular bone , cancellous bone , bone disease , metabolic bone disease , tibia , chemistry , biology , osteoporosis , anatomy , alkaline phosphatase , biochemistry , enzyme
Matched samples of bone from the lumbar spine and tibia were obtained at autopsy from three adult males who had no known evidence of metabolic bone disease at the time of their demise. The soluble noncollagenous bone proteins were quantitatively extracted from these samples and assayed for the relative content of two bone‐associated proteins, osteocalcin and osteonectin. When compared to trabecular bone, cortical bone had higher levels of osteocalcin and much lower levels of osteonectin. When concentration is expressed per gram of dried bone, the osteocalcin excess in cortical bone ranged from 30‐ to 32‐fold, and the osteonectin excess in trabecular bone ranged from 21‐ to 47‐fold. These differences were significant ( P < 0.01) using analysis of variance. We conclude that the human skeleton is not homogeneous with regard to these biochemical markers and that cortical and trabecular bone are biochemically quite distinct. This implies that these two types of bone may be subject to distinct regulatory mechanisms and that global assessments of skeletal function and bone quality based upon soluble markers should be applied with caution. The data also imply that a differential assessment of skeletal performance may be possible using biochemical serum markers.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here