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Osteoporosis as the sole presentation of bone marrow mastocytosis
Author(s) -
Lidor Cobi,
Frisch Bertha,
Gazit Dan,
Gepstein Reuven,
Hallel Tom,
Mekori Yoseph A.
Publication year - 1990
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650050811
Subject(s) - systemic mastocytosis , medicine , bone marrow , cutaneous mastocytosis , osteopenia , osteoporosis , mast cell , pathology , immunology , bone mineral
Three (young) adults with severe generalized osteopenia and vertebral compression fractures were studied. Extensive clinical and laboratory investigations were not contributory. Undecalcified bone biopsies demonstrated multiple mast cell granulomas in the marrow in two patients and numerous mast cells diffusely distributed throughout the bone marrow in the third patient. Mast cells may serve as a pathogenic agent in osteoporosis. Therefore, we conclude that isolated skeletal mastocytosis without clinical evidence of mast cell mediator release should be sought in the evaluation of a patient with unexplained severe bone loss.