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Interleukin‐6 is produced by bone and modulated by parathyroid hormone
Author(s) -
Feyen Jean H.M.,
di Padova Franco E.,
Trechsel Ulrich,
Elford Peter
Publication year - 1989
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650040422
Subject(s) - parathyroid hormone , hormone , medicine , endocrinology , bone remodeling , immune system , interleukin , biology , chemistry , cytokine , immunology , calcium
Abstract Interleukin‐6 (IL‐6) is a cellular regulatory molecule, the diverse functions of which relate to cells both within and outside the immune system. In this report we demonstrated that bone tissue, specifically osteoblasts, produce interleukin‐6 and that this function can be modulated by the osteotrophic hormone parathyroid hormone (PTH). Given that the complex process of bone remodeling is now thought to be regulated not only by systemic hormones but also by locally produced factors, the existence of a parathyroid hormone‐stimulated production of interleukin‐6 by osteoblasts may have important physiological significance.