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Bone mineral density in women with type II diabetes mellitus
Author(s) -
Weinstock Ruth S.,
Goland Robin S.,
Shane Elizabeth,
Clemens Thomas L.,
Lindsay Robert,
Bilezikian John P.
Publication year - 1989
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650040114
Subject(s) - medicine , bone mineral , diabetes mellitus , endocrinology , type 1 diabetes , bone density , osteoporosis
Bone mineral density (BMD) was assessed in 28 women with type II diabetes mellitus and compared to 207 age‐matched nondiabetic women. Mean BMD, as measured by dual‐photon absorptiometry, 1.12 ± 0.3 g/cm 2 (±SEM), was similar to the mean BMD of control subjects, 1.06 ± 0.1 g/cm 2 . Only 1 of the 28 diabetic patients had a BMD less than 0.95 g/cm 2 (“fracture threshold”), whereas 25% of the control subjects had a BMD below that level. When diabetic and control subjects were matched for weight as well as age, the data continued to show similar BMD among both groups. Moreover, the disparity between the proportion of weight‐matched controls (25%) and diabetic subjects (1 of 28) with a BMD below the fracture threshold persisted. Among the group of 17 diabetic subjects receiving insulin, there was a positive relationship between BMD and insulin dose. There was no significant relationship between BMD, duration of diabetes, or hemoglobin A 1c . Thus, women with type II diabetes are not at increased risk for diminished BMD and may be protected against bone loss.