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Cellular basis of inflammation‐induced osteopenia in growing rats
Author(s) -
Krempien B.,
Vukičević S.,
Vogel M.,
Stavljenić A.,
Böchele R.
Publication year - 1988
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650030514
Subject(s) - osteopenia , metaphysis , inflammation , bone marrow , medicine , endocrinology , osteoporosis , anatomy , bone mineral
Local nonosseous inflammation provoked by four subcutaneous talc powder injections induced a marked trabecular bone loss in rats within 7 days. The disturbance included suppression of bone elongation, inefficiency and decreased number of trabecular osteoblasts, decreased osteoprogenitor cell number in tibial metaphyses, and bone marrow expansion. Neither the appearance and function of osteoblasts in the vicinity of the cortical bone nor the number of osteoclasts in the metaphysis were found to be altered. The loss of trabecular bone in granulomatosis was based on a suppression of bone elongation and a failure of osteoblasts to form normal secondary spongiosa.