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Interferon‐inhibited human osteosarcoma xenografts induce host bone in nude mice
Author(s) -
Forster Simon,
Triffitt James T.,
Bauer Henrik C.F.,
Brosjö Otte,
Nilsson Olle S.,
Smith Roger,
Sykes Bryan
Publication year - 1988
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650030212
Subject(s) - osteosarcoma , interferon , pathology , bone tissue , nude mouse , cancer research , stroma , chemistry , biology , immunohistochemistry , immunology , cell culture , medicine , genetics
Abstract The growth of human osteosarcoma xenografts in nude mice can be inhibited by human interferon‐alpha (IFN‐α). Histologic examination of growth‐inhibited tumors has revealed mineralization and partial replacement of the tumor by normal bone tissue. We have investigated whether the normal bone tissue was formed by differentiated tumor cells or by induction of host stroma to differentiate into bone tissue. Employing antibodies to both murine and human type I collagen, it was found that the normal bone produced in IFN‐inhibited osteosarcomas was host derived. These results suggest that IFN induced the osteosarcoma cells to produce a bone‐inductive agent that interacts with the host cells, and leads to the formation of mature normal bone tissue in a heterotopic site.