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Bone turnover in spinal osteoporosis
Author(s) -
Pødenphant Jan,
Johansen Julia Sidenius,
Thomsen Karsten,
Riis Bente Juel,
Leth Arne,
Christiansen Claus
Publication year - 1987
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650020606
Subject(s) - bone resorption , resorption , hydroxyproline , endocrinology , medicine , osteoporosis , bone remodeling , creatinine , urinary system , bone disease , urology , chemistry
We have investigated biochemical indices of bone formation and bone resorption: serum alkaline phosphatase (sAP) plasma bone Gla protein (pBGP), fasting urinary hydroxyproline corrected for creatinine (FuHP/Cr), and fasting urinary calcium corrected for creatinine (FuCa/Cr) in 43 postmenopausal women with spinal fractures. Furthermore, histomorphometric indices of bone resorption and bone formation, as well as whole body retention (WBR) of 99m‐technetium‐diphosphonate ( 99m Tc‐DP), were determined. The results are compared to pre‐ and postmenopausal normal subjects. The results showed that indices of bone formation were mutually correlated except for sAP vs. WBR. sAP, WBR, and pBGP increased with age. sAP and WBR were not different between osteoporotics and age‐matched controls, while pBGP and probably histological indices of bone formation were lower in osteoporotics than in age‐matched controls. pBGP—and to a lesser extent sAP—were significantly correlated with all histological parameters reflecting bone formation. Finally, biochemical indices of bone resorption were high in osteoporotic patients and poorly correlated with histological bone resorption. The discrepancy between biochemical markers of bone formation may be related to the low sensitivity of sAP and WBR. Conversely, pBGP, sAP, and WBR may reflect different aspects of osteoblastic activity and bone mineralization. Finally, our data suggest that bone turnover increases with aging and that osteoporotic patients have higher bone resorption and probably lower bone formation than age‐matched controls.