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The effect of oral phosphate administration on major indices of skeletal metabolism in normal subjects
Author(s) -
Silverberg Shonni J.,
Shane Elizabeth,
Clemens Thomas L.,
Dempster David W.,
Segre Gino V.,
Lindsay Robert,
Bilezikian John P.
Publication year - 1986
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650010412
Subject(s) - medicine , endocrinology , parathyroid hormone , hydroxyproline , phosphate , chemistry , bone remodeling , calcium , metabolism , osteoporosis , oral administration , urinary system , biochemistry
The effect of brief periods of phosphate administration on indices of human skeletal metabolism was investigated. Thirteen subjects (8 women, 5 men; 19–36 years old) received 2 g of oral phosphate daily for 5 days. Serum phosphorus rose 26% (3.8 ± 0.1 mg/dl to 4.8 ± 0.1 mg/dl; p < .01) while total calcium fell (9.3 ± 0.1 mg/dl to 8.9 ± 0.1 mg/dl; p < .01). Parathyroid hormone levels increased by 50% (14.1 ± 2.0 pg/ml to 21.5 ± 1.7 pg/ml; p < .05) although values remained within the normal range. A persistent phosphaturia (0.64 ± 0.10 g/g Cr to 1.8 ± 0.4 g/g Cr; p < .05) and a 69% fall in urinary calcium (80.8 ± 10.0 mg/g Cr to 24.6 ± 6.0 mg/g Cr; p < .001) were observed. 1,25‐dihydroxyvitamin D 3 and urinary hydroxyproline concentrations did not change significantly but the bone γ‐carboxyglutamic acid protein (BGP) concentration rose 41% by day 2 (9.6 ± 1.3 mg/ml to 13.5 ± 2.2 mg/ml; p < .005) and remained elevated throughout the study period. These results support the possibility that brief periods of phosphate administration may be useful in the therapy of disorders associated with low bone turnover, such as osteoporosis.