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Restoration of spinal bone in osteoporotic men by treatment with human parathyroid hormone (1–34) and 1,25‐dihydroxyvitamin D
Author(s) -
Slovik David M.,
Rosenthal Daniel I.,
Doppelt Samuel H.,
Potts John T.,
Daly Margaret A.,
Campbell Julie A.,
Neer Robert M.
Publication year - 1986
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650010411
Subject(s) - osteoporosis , parathyroid hormone , endocrinology , calcium , medicine , calcitriol , vitamin d and neurology , phosphorus , bone mineral , ingestion , hormone , chemistry , organic chemistry
Daily subcutaneous injection of a synthetic human parathyroid hormone fragment, combined with daily ingestion of 1,25(OH) 2 vitamin D, significantly increased trabecular bone density in the spine ( p < .01), and improved intestinal calcium and phosphorus absorption and total body retention of dietary calcium and phosphorus in middle‐aged men with idiopathic osteoporosis. The increases in spinal bone mineral were marked and progressive during a year of treatment. These results indicate that increasing intestinal absorption of dietary calcium while simultaneously stimulating new bone formation with small doses of parathyroid hormone can restore spinal bone in osteoporotic men.