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Cyclosporine a inhibits calcemic hormone‐induced bone resorption in vitro
Author(s) -
Stewart Pamela J.,
Green Orville C.,
Stern Paula H.
Publication year - 1986
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.5650010307
Subject(s) - bone resorption , endocrinology , medicine , parathyroid hormone , resorption , osteoclast , chemistry , prostaglandin e2 , hormone , in vitro , calcium , receptor , biochemistry
We have investigated the in vitro effects of cyclosporine (CsA), a potent immunosuppressive agent, on bone resorption induced by calcemic hormones. CsA inhibited parathyroid hormone (PTH), prostaglandin E 2 , 1,25‐dihydroxy vitamin D 3 (1,25(OH) 2 D 3 ), and osteoclast‐activating factor induced resorption of fetal rat limb bones in a dose‐dependent manner. Established ongoing resorptive activity in bone was also inhibited by CsA. The CsA inhibition of bone resorption could be partially surmounted by higher concentrations of PTH and 1,25(OH) 2 D 3 . The inhibitory effects of CsA on limb bone resorption were reversible. Neither protein nor DNA synthesis were inhibited by treatment of limb bones with CsA. Thus, the inhibitory effect of this agent on bone resorption is not a cytotoxic one. These data could suggest that the induction of bone resorption by the calcemic hormones involves an immune cell derived mediator such as a lymphokine.