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Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor ( COP ) Cells
Author(s) -
Feehan Jack,
Kassem Moustapha,
Pignolo Robert J,
Duque Gustavo
Publication year - 2021
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.4204
Subject(s) - progenitor cell , medicine , progenitor , population , in vitro , mesoderm , microbiology and biotechnology , immunology , stem cell , biology , embryonic stem cell , biochemistry , environmental health , gene
ABSTRACT Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm‐like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research (ASBMR).