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Skeletal muscle fat content is inversely associated with bone strength in young girls
Author(s) -
Farr Joshua N,
Funk Janet L,
Chen Zhao,
Lisse Jeffrey R,
Blew Robert M,
Lee Vinson R,
Laudermilk Monica,
Lohman Timothy G,
Going Scott B
Publication year - 2011
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.414
Subject(s) - quantitative computed tomography , tibia , femur , thigh , medicine , endocrinology , bone density , skeletal muscle , body mass index , adipose tissue , obesity , anatomy , osteoporosis , surgery
Childhood obesity is an established risk factor for metabolic disease. The influence of obesity on bone development, however, remains controversial and may depend on the pattern of regional fat deposition. Therefore, we examined the associations of regional fat compartments of the calf and thigh with weight‐bearing bone parameters in girls. Data from 444 girls aged 9 to 12 years from the Jump‐In: Building Better Bones study were analyzed. Peripheral quantitative computed tomography (pQCT) was used to assess bone parameters at metaphyseal and diaphyseal sites of the femur and tibia along with subcutaneous adipose tissue (SAT, mm 2 ) and muscle density (mg/cm 3 ), an index of skeletal muscle fat content. As expected, SAT was positively correlated with total‐body fat mass ( r = 0.87–0.89, p < .001), and muscle density was inversely correlated with total‐body fat mass ( r = −0.24 to −0.28, p < .001). Multiple linear regression analyses with SAT, muscle density, muscle cross‐sectional area, bone length, maturity, and ethnicity as independent variables showed significant associations between muscle density and indices of bone strength at metaphyseal (β = 0.13–0.19, p < .001) and diaphyseal (β = 0.06–0.09, p < .01) regions of the femur and tibia. Associations between SAT and indices of bone strength were nonsignificant at all skeletal sites (β = 0.03–0.05, p > .05), except the distal tibia (β = 0.09, p = .03). In conclusion, skeletal muscle fat content of the calf and thigh is inversely associated with weight‐bearing bone strength in young girls. © 2011 American Society for Bone and Mineral Research