Premium
Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo
Author(s) -
Duque Gustavo,
Vidal Christopher,
Li Wei,
Al Saedi Ahmed,
Khalil Mamdouh,
Lim Chai K,
Myers Damian E,
Guillemin Gilles J
Publication year - 2020
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.4125
Subject(s) - osteoporosis , picolinic acid , ovariectomized rat , anabolism , endocrinology , in vivo , medicine , catabolite repression , bone mineral , chemistry , bone resorption , population , hormone , biology , biochemistry , microbiology and biotechnology , environmental health , mutant , gene
Fractures attributable to osteoporosis have a severe impact on our older population. Reports of side effects with commonly prescribed osteoporosis drugs have led to the investigation of new and safer treatments with novel mechanisms of action. Picolinic acid (PIC), a catabolite of tryptophan, induces in vitro osteogenic differentiation of mesenchymal stem cells. Here we demonstrate that PIC has an anabolic effect on bone in vivo by increasing bone formation, bone mass, and bone strength in normal and ovariectomized C57BL/6 mice. Activation of the osteogenic pathways triggered this osteoanabolic response without any cross‐related effects on mineral absorption or calciotropic hormones. Because PIC was also well tolerated and absorbed with no side effects, it is an ideal potential candidate for the treatment of osteoporosis. © 2020 American Society for Bone and Mineral Research.