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Circulating osteogenic cells: Implications for injury, repair, and regeneration
Author(s) -
Pignolo Robert J,
Kassem Moustapha
Publication year - 2011
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.370
Subject(s) - regeneration (biology) , microbiology and biotechnology , pathophysiology , biology , medicine , pathology
The aim of this review is to provide a critical reading of recent literature pertaining to the presence of circulating, fluid‐phase osteoblastic cells and their possible contribution to bone formation. We have termed this group of cells collectively as circulating osteogenic precursor (COP) cells. We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues. © 2011 American Society for Bone and Mineral Research