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Agreement between pQCT‐ and DXA‐derived indices of bone geometry, density, and theoretical strength in females of varying age, maturity, and physical activity
Author(s) -
Dowthwaite Jodi Noelle,
Flowers Portia PE,
Scerpella Tamara Ann
Publication year - 2011
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.322
Subject(s) - quantitative computed tomography , bone density , densitometry , dual energy x ray absorptiometry , prepuberty , dual energy , metaphysis , medicine , geometry , bone mineral , nuclear medicine , mathematics , osteoporosis , anatomy , hormone
Measurement of bone mass, geometry, density, and strength are critical in bone research and clinical studies. For peripheral quantitative computed tomography (pQCT), single and repeated measurements are particularly adversely affected by movement and positional variation. Dual‐energy X‐ray absorptiometry (DXA)–derived indices may alleviate these problems and provide useful alternative assessments. To evaluate this hypothesis, distal radius DXA and pQCT indices were compared in 101 healthy females aged 8.0 to 22.8 years (prepuberty to adulthood), reflecting a broad range of body sizes, physical maturity, and activity exposures. At the diaphysis, correlations were ρ = +0.74 to +0.98, with strong intermethod agreement for most indices. At the metaphysis, correlations were ρ = +0.64 to +0.97; intermethod agreement improved with modifications to the simplified geometric formulas more closely reflecting metaphyseal bone geometry. Further improvements may be possible because skeletal size and maturity‐related biases in agreement were detected. Overall, DXA‐derived indices may provide a useful assessment of bone geometry, density, and theoretical strength contingent on appropriate consideration of their limitations. © 2011 American Society for Bone and Mineral Research.