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The Road to Reproducibility in Animal Research
Author(s) -
Jilka Robert L
Publication year - 2016
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.2881
Subject(s) - transparency (behavior) , animal testing , reproducibility , preclinical research , medicine , engineering ethics , computer science , medical physics , biology , engineering , mathematics , ecology , statistics , computer security
ABSTRACT Reproducibility of research findings is the hallmark of scientific advance. However, the recently noted lack of reproducibility and transparency of published research using animal models of human biology and disease has alarmed funders, scientists, and the public. Improved reporting of methodology and better use of statistical tools are needed to enhance the quality and utility of published research. Reporting guidelines like Animal Research: Reporting In Vivo Experiments (ARRIVE) have been devised to achieve these goals, but most biomedical research journals, including the JBMR , have not been able to obtain high compliance. Cooperative efforts among authors, reviewers and editors—empowered by increased awareness of their responsibilities, and enabled by user‐friendly guidelines—are needed to solve this problem. © 2016 American Society for Bone and Mineral Research.