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Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain
Author(s) -
Hamilton John L,
Nagao Masashi,
Levine Brett R,
Chen Di,
Olsen Bjorn R,
Im HeeJeong
Publication year - 2016
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.2828
Subject(s) - osteoarthritis , medicine , vascular endothelial growth factor , synovitis , vegf receptors , cartilage , angiogenesis , receptor , bioinformatics , pathology , oncology , arthritis , biology , alternative medicine , anatomy
ABSTRACT Increased vascular endothelial growth factor (VEGF) levels are associated with osteoarthritis (OA) progression. Indeed, VEGF appears to be involved in OA‐specific pathologies including cartilage degeneration, osteophyte formation, subchondral bone cysts and sclerosis, synovitis, and pain. Moreover, a wide range of studies suggest that inhibition of VEGF signaling reduces OA progression. This review highlights both the potential significance of VEGF in OA pathology and pain, as well as potential benefits of inhibition of VEGF and its receptors as an OA treatment. With the emergence of the clinical use of anti‐VEGF therapy outside of OA, both as high‐dose systemic treatments and low‐dose local treatments, these particular therapies are now more widely understood. Currently, there is no established disease‐modifying drug available for patients with OA, which warrants continued study of the inhibition of VEGF signaling in OA, as stand‐alone or adjuvant therapy. © 2016 American Society for Bone and Mineral Research.