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Small Players Ruling the Hard Game: siRNA in Bone Regeneration
Author(s) -
Ghadakzadeh Saber,
Mekhail Mina,
Aoude Ahmed,
Hamdy Reggie,
Tabrizian Maryam
Publication year - 2016
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.2816
Subject(s) - regeneration (biology) , small interfering rna , gene silencing , medicine , bioinformatics , biology , rna , microbiology and biotechnology , gene , genetics
Silencing gene expression through a sequence‐specific manner can be achieved by small interfering RNAs (siRNAs). The discovery of this process has opened the doors to the development of siRNA therapeutics. Although several preclinical and clinical studies have shown great promise in the treatment of neurological disorders, cancers, dominant disorders, and viral infections with siRNA, siRNA therapy is still gaining ground in musculoskeletal tissue repair and bone regeneration. Here we present a comprehensive review of the literature to summarize different siRNA delivery strategies utilized to enhance bone regeneration. With advancement in understanding the targetable biological pathways involved in bone regeneration and also the rapid progress in siRNA technologies, application of siRNA for bone regeneration has great therapeutic potential. High rates of musculoskeletal injuries and diseases, and their inevitable consequences, impose a huge financial burden on individuals and healthcare systems worldwide. © 2016 American Society for Bone and Mineral Research.