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Role of Decorin in Multiple Myeloma (MM) Bone Marrow Microenvironment
Author(s) -
Nemani Neeharika,
Santo Loredana,
Eda Homare,
Cirstea Diana,
Mishima Yuko,
Patel Chirayu,
O'Donnell Elizabeth,
Yee Andrew,
Raje Noopur
Publication year - 2015
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.2371
Subject(s) - decorin , proteoglycan , extracellular matrix , multiple myeloma , cancer research , tumor microenvironment , chemistry , immunology , microbiology and biotechnology , pathology , medicine , biology , tumor cells
Decorin is a small, leucine‐rich proteoglycan found in the extracellular matrix of various connective tissues with potential effective tumor suppressive properties. Recent data suggest low levels of decorin in multiple myeloma (MM) patients compared to healthy volunteers, as well as in patients with osteolytic bone lesions compared to non‐osteolytic lesions. In the present report, we investigated the role of decorin in the MM microenvironment or niche. Our data suggests that decorin is produced by osteoblasts (OBs) but not by MM cells. Furthermore, MM cells decrease OB‐induced decorin secretion and this effect is mediated by CCL3. Importantly, neutralizing CCL3 from MM cells restores decorin levels in OBs as does proteasome inhibitors such as carfilzomib. These findings indicate that decorin may indirectly act as an antagonist to MM cell survival and that the interplay between MM and decorin may be an important target to explore in manipulating the tumor niche to inhibit tumorigenesis. © 2014 American Society for Bone and Mineral Research.