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Standardizing Vitamin D Assays: The Way Forward
Author(s) -
Binkley Neil,
Sempos Christopher T
Publication year - 2014
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.2252
Subject(s) - vitamin d and neurology , medicine , computational biology , biology
ABSTRACT For a number of years it has been widely assumed that measurement of serum 25‐hydroxyvitamin D [25(OH)D] concentration is the best approach to assessing an individual's vitamin D status.[1][, 2011], [2][Holick MF, 2011] However, it has also been recognized that there is substantial within‐assay variation in 25(OH)D measurement and even greater between‐assay variability.[3][Binkley N, 2004], [4][Carter GD., 2011], [5][Lai JK, 2012] Such assay variation clearly confounds attempts to define what constitutes the diagnosis of hypovitaminosis D. Importantly, assay variability makes pooling of 25(OH)D results from different studies in systematic reviews for the specific purpose of determining dose‐response and/or clinical cut points at best problematic. Therefore, to develop and implement evidence‐based clinical guidelines, it is essential that 25(OH)D measurement be standardized in both clinical and research laboratories. In this Perspective we outline a way forward toward achieving this goal—the Vitamin D Standardization Program (VDSP). © 2014 American Society for Bone and Mineral Research