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The Primary Function of gp130 Signaling in Osteoblasts Is To Maintain Bone Formation and Strength, Rather Than Promote Osteoclast Formation
Author(s) -
Johnson Rachelle W,
Brennan Holly J,
Vrahnas Christina,
Poulton Ingrid J,
McGregor Narelle E,
Standal Therese,
Walker Emma C,
Koh ThuanTzen,
Nguyen Huynh,
Walsh Nicole C,
Forwood Mark R,
Martin T John,
Sims Natalie A
Publication year - 2014
Publication title -
journal of bone and mineral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.882
H-Index - 241
eISSN - 1523-4681
pISSN - 0884-0431
DOI - 10.1002/jbmr.2159
Subject(s) - osteoblast , osteocyte , sclerostin , osteoclast , bone remodeling , chemistry , endocrinology , microbiology and biotechnology , medicine , cortical bone , bone cell , biology , signal transduction , anatomy , in vitro , biochemistry , wnt signaling pathway
Interleukin‐6 (IL‐6) family cytokines act via gp130 in the osteoblast lineage to stimulate the formation of osteoclasts (bone resorbing cells) and the activity of osteoblasts (bone forming cells), and to inhibit expression of the osteocyte protein, sclerostin. We report here that a profound reduction in trabecular bone mass occurs both when gp130 is deleted in the entire osteoblast lineage (Osx1Cre gp130 f/f) and when this deletion is restricted to osteocytes (DMP1Cre gp130 f/f). This was caused not by an alteration in osteoclastogenesis, but by a low level of bone formation specific to the trabecular compartment. In contrast, cortical diameter increased to maintain ultimate bone strength, despite a reduction in collagen type 1 production. We conclude that osteocytic gp130 signaling is required for normal trabecular bone mass and proper cortical bone composition. © 2014 American Society for Bone and Mineral Research.